Evidence map›Paper›PMID 41425662›Full record

ArticleDepression and anxiety2025

Brain Network Controllability and Its Regional Gene Expression Profile Associated With Suicidal Tendencies in Major Depressive Disorder Patients.

Xinyi Liu, Cancan He, Dandan Fan, Sangni Liu, Haisan Zhang, Zhijun Zhang, Hongxing Zhang, Chunming Xie, Xianxian Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyi LiuDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.
Cancan HeDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.
Dandan FanDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.
Sangni LiuDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.
Haisan ZhangDepartment of Radiology, Henan Provincial Mental Hospital, Xinxiang Medical University, Xinxiang, 453003, Henan, China, xxmu.edu.cn.
Zhijun ZhangDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.ORCID 0000-0001-5480-0888
Hongxing ZhangHenan Key Laboratory of Psychology and Behavior, Xinxiang Medical University, Xinxiang, 453003, Henan, China, xxmu.edu.cn.
Chunming XieDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China, seu.edu.bd.ORCID 0000-0002-5978-9689
Xianxian ZhangDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, 224008, Jiangsu, China, seu.edu.bd.ORCID 0000-0001-5637-507X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suicidality is the most severe sign of major depressive disorder (MDD). However, network-wide structural dynamics alterations and transcriptional patterns in MDD patients with suicidality remain unclear. A total of 124 participants were recruited, including 31 MDD patients without suicidal ideation (MDDNSI), 34 MDD patients with suicidal ideation (MDDSI), 22 MDD patients with suicidal behavior (MDDSB), and 37 healthy controls (HCs). All participants completed diffusion tensor imaging scans and suicidal assessment. Network-based statistics (NBSs) were used to compare differences in structural connectivity, while average network controllability (ANC) reflecting brain state dynamics was measured based on suicidality-based circuits. Weighted gene coexpression network analysis (WGCNA) identified gene modules associated with neuroimaging phenotypes. Gene functions and cellular types in MDD patients were determined with enrichment analysis and cell-type-specific expression analysis. The results showed that in the suicidal ideation (SI) circuit, MDDSI patients represented decreased ANC compared to MDDNSI patients, with upregulated genes related to neuronal bundles and downregulated genes related to ribosomes. In the suicidal behavior (SB) circuit, MDDSB patients exhibited reduced ANC compared to MDDNSB patients, with upregulated genes associated with cytoplasmic pathways and positive regulation of signaling and downregulated genes related to synaptic signal transmission. Importantly, genes in both the SI circuit and SB circuit were enriched in gamma-aminobutyric acid (GABA) neurons. The study highlights that the differential ANC of the SI network and the SB network exerts a distinctive influence on brain state trajectories in MDD patients and identifies the specific transcriptional pattern and cell types associated with brain regions related to SI or SB in depression.

Indexed as

BrainGene Regulatory NetworksMajor Depressive DisorderNerve NetSuicidal IdeationTranscriptomeAdultDiffusion Tensor ImagingFemaleGene Expression ProfilingHumansMaleMiddle Agedaverage controllabilitydiffusion tensor imaging (DTI)major depressive disorder (MDD)network-based statistics (NBS)weighted gene coexpression analysis (WGCNA)

Identifiers

PMID41425662
PMCPMC12714167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.