Evidence map›Paper›PMID 41425632›Full record

ReviewFrontiers in nutrition2025

Dietary melanoidins as emerging functional components: interactions with gut microbiota and implications for nutritional modulation of intestinal health.

Jialiang Chen, Xiaoyi Gao, Yue Hou, Guowei Liang

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jialiang ChenDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.
Xiaoyi GaoTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Yue HouTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Guowei LiangDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoidins, complex brown polymers formed during the Maillard reaction in thermally processed or fermented foods, are increasingly recognized for their nutritional relevance beyond sensory contributions. Emerging evidence suggests that they may act as prebiotic-like compounds that resist human digestion and undergo microbial fermentation in the colon, producing metabolites such as short-chain fatty acids (SCFAs). These metabolites are proposed to support intestinal barrier function, inflammation, and host metabolism. This review summarizes current knowledge on the gastrointestinal fate, microbial fermentation, and putative bioactivities of dietary melanoidins, with a focus on their interactions with gut microbiota. We compare the structural diversity among food sources and discuss potential health implications. However, most evidence to date derives from

Indexed as

gut microbiotaMaillard reactionmelanoidinsprebioticsshort-chain fatty acids

Identifiers

PMID41425632
PMCPMC12713420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.