ArticleFrontiers in immunology2025
Bowman's capsule rupture and its clinical significance in patients with anti-glomerular basement membrane disease.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anti-glomerular basement membrane (GBM) disease represents the most severe form of crescentic glomerulonephritis. Previous studies demonstrated that Bowman's capsule rupture contributed to the progression of crescentic glomerulonephritis. However, its role in anti-GBM disease remains unclear. The aim of this study was to investigate the prevalence and severity of Bowman's capsule rupture in patients with anti-GBM disease and its clinical associations. Methods: A total of 72 patients diagnosed with biopsy-proven anti-GBM disease with complete clinical and pathologic data were retrospectively enrolled. Results: Extensive Bowman's capsule rupture occurred in 70 patients (97.2%) with a median percentage of 52.8% of all glomeruli on each kidney biopsy. The percentage of Bowman's capsule rupture showed a strong association with kidney injuries (incidence of oligoanuria, eGFR, and serum creatinine on diagnosis; Conclusions: Bowman's capsule rupture serves as both a distinct histopathological feature and a critical determinant of kidney injury in anti-GBM disease. More importantly, as a simple, standalone parameter, it demonstrates a robust predictive value for kidney outcomes in patients with anti-GBM disease.
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