ArticleFrontiers in immunology2025
Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lung adenocarcinoma remains a leading cause of cancer mortality, necessitating novel prognostic biomarkers and therapeutic targets. Ubiquitination, a crucial post-translational modification, is deeply implicated in tumourigenesis. This study aims to identify key ubiquitination-related regulators in LUAD and investigate their clinical significance, with a particular focus on Methods: We analysed transcriptomic data from TCGA and GEO databases to identify survival-related ubiquitination genes. Proteomic data from the CPTAC database validated key findings. Functional enrichment, immune cell infiltration, and single-cell RNA sequencing (scRNA-seq) analyses were performed to explore the role of Results: Conclusions: Our study identifies
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