Evidence map›Paper›PMID 41425566›Full record

ArticleFrontiers in immunology2025

Transcriptome analysis of differences in the infection of African swine fever virus (SY-1 strain) in iPAMs and PAMs.

Haiying Mao, Chuxing Cheng, Yong Wang, Wenhui Zhou, Ke Zhang, Yongqi Wang, Lihao Wang, Zhenrui Song, Xiaomei Sun, Yuanfeng Zhang and 6 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Haiying MaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Chuxing ChengState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yong WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Wenhui ZhouState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Ke ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yongqi WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Lihao WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zhenrui SongState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Xiaomei SunState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yuanfeng ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Xiaotong HuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yumei ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zong ZouState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Ya ZhaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Qiang ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Meilin JinState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever (ASF) is a highly contagious hemorrhagic disease caused by African swine fever virus (ASFV), which has inflicted devastating impacts on the global swine industry. Currently, no commercially available vaccines exist. A major obstacle in ASF research of mechanistic exploration and vaccine studies is the virus's strict tropism for primary cells like porcine alveolar macrophages (PAMs), while exhibiting poor susceptibility to most immortalized cell lines. This study compared the replication and host response of the ASFV SY-1 strain in PAMs versus immortalized porcine macrophage cell lines (iPAMs) using qPCR, western blot, and early infection transcriptome data. Results revealed that the SY-1 strain replicates only minimally in iPAMs, with significantly lower replication capacity than in PAMs. Transcriptomic data demonstrated divergent host responses: iPAMs predominantly involved in in the regulation of lipid metabolism and response to oxidative stress, whereas PAMs preferentially activate cytokine signaling and immune responses. Furthermore, Functional validation indicated

Indexed as

African Swine FeverAfrican Swine Fever VirusMacrophages, AlveolarTranscriptomeAnimalsCell LineGene Expression ProfilingHost-Pathogen InteractionsSwineVirus ReplicationAfrican swine fever virusiPAMsJPH4 and CYP1A1PAMSSY-1 straintranscriptomic analysisviral replication

Identifiers

PMID41425566
PMCPMC12714971

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