SynthesisFrontiers in immunology2025
Visualized knowledge mapping on the current research trends and emerging areas of neuroimmune modulation in the past two decades.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Reference data analysis and visualization methods were applied to identify current knowledge mapping methods in the neuroimmune modulation research field. Methods: A comprehensive search of publications within the field of neuroimmune modulation in the Web of Science Core Collection database and PubMed from 2005-2024 was conducted. The reference type was restricted to articles and reviews in the WOSCC database and clinical trials in PubMed. The data were visualized and analyzed via visualization and bibliometric tools, including CiteSpace and VOSviewer. Results: A total of 5,280 publications were included in the field of neuroimmune modulation. The United States ranked first as the most influential country in terms of both publication number and academic influence. Harvard University had the greatest impact on institutions. The leading scientists in the neuroimmune modulation field have focused on the mechanism at both the peripheral and central levels. Citation analysis and cocitation analysis revealed that acute kidney injury, neuropathic pain, and neuronal regulation are key focal points in neuroimmune research. Furthermore, keyword analysis revealed that "inflammation", "neuroinflammation", "microglia", "cytokines", "cholinergic anti-inflammatory pathway" and "neuroimmune" had more than 200 co-occurrences and represented research hotspots in this field. A total of 73 clinical trials were identified that targeted neuroimmune modulation to treat diseases. These studies highlighted the central role of the neuroimmune network in diseases, with a particular emphasis on innovative therapies that regulate inflammation through the cholinergic system. Further exploration is needed to develop precise intervention strategies targeting specific cytokines. Conclusions: This analysis provides comprehensive knowledge mapping in the current research field of neuroimmune modulation. The trends in the field include mechanism studies combined with neuronal regulation. Neuroimmune crosstalk might provide new therapeutic targets for treating nervous system diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.