ArticleACS measurement science au2025
Non-Targeted Analysis Workflow of Endocrine-Disrupting Chemicals in Ovarian Follicular Fluid: Identification of Parabens by Diagnostic Fragmentation Evidence and Additional Contaminants via Mass Spectral Library Matching.
Article in ACS measurement science au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Ubiquitously distributed in the environment, food supply, and consumer products, endocrine-disrupting chemicals (EDCs) are exogenous substances that disrupt hormonal activities in the endocrine system. Increasing evidence suggests that women with reproductive disorders tend to accumulate higher levels of EDCs, such as phthalates and parabens, in ovarian follicular fluid. However, most existing studies focus on the measurements of a limited number of prevalent EDCs, overlooking chemicals and metabolites that are not known or prioritized. To address the knowledge gap, we developed a non-targeted analysis (NTA) workflow for broader EDC detection in follicular fluid samples using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). By taking advantage of the higher-energy collisional dissociation (HCD) in the Orbitrap mass spectrometer, we first identified up to 17 characteristic product ions for parabens and their metabolites. Compared to conventional mass spectral matching via online databases and
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