ArticleACS measurement science au2025
Sampling Probes Microfabricated from Parylene‑C for In Vivo Neurochemical Monitoring.
Article in ACS measurement science au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
6 authors.
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Abstract
Monitoring chemistry in the central nervous system in vivo is an important route to better understand chemical signals and metabolism underlying brain function. Sampling from the brain extracellular space allows for in depth and multiplexed analysis of this compartment. Miniaturized sampling devices prepared by using microfabrication are emerging as tools that allow high spatial resolution measurements with low invasiveness. In this work, we describe a microfabrication method for Parylene-C-based push-pull sampling probes. Parylene-C is an attractive material because its biocompatibility and flexibility may allow for chronic measurements. Probes with 3 mm long shanks and 45 × 166 μm cross sections were prepared and tested for suitability for in vivo experiments. Two designs, one with push-pull orifices on the probe tip and the other with the orifices recessed ∼40 mm within a sheath of Parylene-C, were investigated. The sheathed probes successfully flowed in tofu (
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