ArticleThe Journal of the Canadian Chiropractic Association2025
The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.
Article in The Journal of the Canadian Chiropractic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- When there is little or no research evidence: a clinical decision tool.The Journal of the Canadian Chiropractic Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic musculoskeletal (MSK) pain is a leading cause of disability affecting patients and healthcare systems worldwide. Its burden is expected to rise sharply due to the aging global population. Given that chronic MSK pain is the most common condition treated by chiropractors daily, chiropractic is ideally positioned to assume a unique leadership role in the future health delivery system of managing this growing clinical challenge. Central sensitization (CS) is linked to an increasing number of chronic pain conditions characterized by increased sensory, sympathetic, and motor excitability. Accumulating evidence suggests that spinal manipulation may achieve its therapeutic benefits by modulating CS, thereby making it a potentially effective non-invasive approach to treating and managing chronic MSK pain. This review aims to provide a discussion of some of the scientific foundations underpinning the pathophysiologic mechanisms of chronic MSK pain and spinal manipulative therapy, as they relate to the contemporary neurophysiologic paradigm of chiropractic medicine and practice. Author’s Note: This paper is one of seven in a series exploring contemporary perspectives on the application of the evidence-based framework in chiropractic care. The Evidence Based Chiropractic Care (EBCC) initiative aims to support chiropractors in their delivery of optimal patient-centred care. We encourage readers to review all papers in the series.
Indexed as
Identifiers
41425291PMC12716896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.