Evidence map›Paper›PMID 41425247›Full record

ArticleMicrobial cell (Graz, Austria)2025

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in

Angela Cirigliano, Antonia Amelina, Elena Passarini, Alessandra Ricelli, Nicole Balasco, Mattia Mori, Bruno Botta, Maria Egle De Stefano, Claudio Papotto, Claudia Guerriero and 2 more

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In one paragraph

Article in Microbial cell (Graz, Austria), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Angela CiriglianoInstitute of Molecular Biology and Pathology, CNR c/o Department of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Antonia AmelinaDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Elena PassariniDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Alessandra RicelliInstitute of Molecular Biology and Pathology, CNR c/o Department of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Nicole BalascoInstitute of Molecular Biology and Pathology, CNR c/o Department of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
Bruno BottaDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Maria Egle De StefanoDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Claudio PapottoDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
Claudia GuerrieroDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Ada Maria TataDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Teresa RinaldiDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is a malignant astrocytic tumor of the brain. A significantly decrease of glioblastoma cell proliferation and survival can be achieved by activating the M2 muscarinic acetylcholine receptor (a G protein-coupled receptor, or GPCR) with two agonist molecules, the orthosteric agonist Arecaidine Propargyl Ester (APE) and the dual-steric agonist Iper-8-naphthalimide (N-8-Iper). In glioblastoma cells, these agonists caused mitochondrial damage and an altered lipid profile. To characterize the mitochondrial dysfunction induced by the muscarinic agonists, we tested APE and N-8-Iper in

Indexed as

dualsteric agonistergosterolGlioblastomaM2 muscarinic receptormitochondrial DNAmodeling in S. cerevisiaeorthosteric agonist

Identifiers

PMID41425247
PMCPMC12713414

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.