ArticleFrontiers in physiology2025
Muscle oxygen consumption and microvascular function in healthy aging assessed by near-infrared spectroscopy: effect of adipose tissue thickness and physical fitness.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sex comparisons across different indices of vascular health in recreationally active healthy adults.European journal of applied physiology · 2026Article
- Skeletal muscle microvascular and respiratory responses to exercise in healthy and T2D adults: agreement and reproducibility study of NIRS technologies.European journal of applied physiology · 2026Article
- Monte Carlo-based correction of geometric and instrumental biases in single-distance time-domain near-infrared spectroscopy on skeletal muscle.Biomedical optics express · 2026Article
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Authors and funding
3 authors.
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Abstract
A decline in skeletal muscle function is a key factor contributing to reduced functional capacity and quality of life with aging. While the mechanisms are multifactorial, impairments in mitochondrial and microvascular function are believed to play a central role. Near-infrared spectroscopy (NIRS) has emerged as a promising non-invasive tool for identifying aging biomarkers and evaluating interventions to preserve muscle health. However, aging often coincides with reduced physical fitness due to lifestyle changes, while age-related changes in body composition further complicate the identification of biomarkers using NIRS. This study investigated aging effects on microvascular and mitochondrial function in healthy adults and explored how physical performance and body composition influence these functions. Eighteen healthy young adults (25.8 ± 2.3 years) and eighteen healthy older adults (69.8 ± 6.0 years) participated. Mitochondrial and microvascular function in arm and leg muscles were simultaneously measured using NIRS during and following vascular occlusion. Physical fitness was evaluated through graded cycling and handgrip tests, and body composition by skinfold thickness and bioimpedance analysis. Data were analyzed using repeated measures ANOVA and multiple regression analysis. Although baseline muscle oxygen saturation (SmO
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