Evidence map›Paper›PMID 41425156›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Synoviocyte-chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects

Shahid Khan, Hongsik Cho, Karen A Hasty, Taylor Brown, Sarayu Bhogoju, Anuradha Subramanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shahid KhanDepartment of Biotechnology Science and Engineering logical Sciences, University of Alabama-Huntsville, Huntsville, AL, United States.
Hongsik ChoDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Sciences Center-Campbell Clinic, Memphis, TN, United States.
Karen A HastyVA Medical Center, Memphis, TN, United States.
Taylor BrownDepartment of Chemical and Materials Engineering, University of Alabama-Huntsville, Huntsville, AL, United States.
Sarayu BhogojuDepartment of Chemical and Materials Engineering, University of Alabama-Huntsville, Huntsville, AL, United States.
Anuradha SubramanianDepartment of Chemical and Materials Engineering, University of Alabama-Huntsville, Huntsville, AL, United States.

Funding

RRD VA I01 RX004283
6 · The paper itself

Abstract

Post-traumatic osteoarthritis (PTOA), a subtype of osteoarthritis initiated by joint trauma, is driven by unresolved early inflammation that ultimately leads to cartilage degeneration. Although animal models have advanced our understanding of disease progression, they offer limited resolution of the early molecular events following trauma. In this study, we developed a transwell-based

Indexed as

chondrocytesdamage-associated molecular patternfibroblasts-like synoviocytesfibronectin fragmentsmacrophagespost-traumatic osteoarthritispost-traumatic osteoarthritis modelTHP-1 monocytes

Identifiers

PMID41425156
PMCPMC12711863

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.