ReviewFrontiers in bioengineering and biotechnology2025
Hydrogels with reversible stiffness modulation: new materials for studying dynamic mechanical cues that regulate cell behavior.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Application of hydrogels in 3D tumor microenvironment modeling and drug screening for cervical cancer: A review.Bioengineering & translational medicine · 2026Review
- Venous Nanoflap Oscillations: Biomechanical Determinants and Hydrodynamic Consequences in the Deep Cerebral Venous System.International journal of molecular sciences · 2026Review
- Mechanomedicine-guided mechanical preconditioning of dental-derived stromal cells for tissue regeneration.Stem cell research & therapy · 2026Review
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the fundamental environment for cell survival, the extracellular matrix (ECM) not only serves as the substrate for cell function and structure formation but also guides cell activities through its dynamic physical properties. Therefore, the relationships by which the physical and mechanical properties of the ECM guide cell behavior such as growth, development, differentiation and reproduction are important to understand. Because substrate stiffness is an important physical property that influences cell behavior, this paper focuses on the relationship between stiffness and cell behavior. Hydrogels, as networks of hydrophilic polymer chains, are an excellent model for the physical properties of the ECM in cellular studies due to its multiple similarities with the ECM. This review classifies hydrogels in terms of their origin and their relative stiffness and presents an overview of their formation, properties, regulation, and applications. We believe that hydrogels with variable elastic moduli will continue to be of considerable use in future studies to further elucidate the effects of mechanical cues on cell behavior.
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Registered trials
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