ArticleClinical, cosmetic and investigational dermatology2025
Global Burden and Trends of Cutaneous Malignant Melanoma in the Elderly Population: Analysis of Global Burden of Disease Study 2021.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comment on "Artificial Intelligence in melanoma research: a bibliometric analysis".International journal of surgery (London, England) · 2026Article
- Global Burden and Drivers of Cutaneous Malignant Melanoma Among Women Aged 55 and Older.International journal of women's health · 2026Article
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Authors and funding
10 authors.
Funding
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Abstract
Background: Cutaneous malignant melanoma (CMM) represents a substantial health burden for the elderly; however, data regarding its impact and epidemiology within this demographic remain scarce. This study aims to evaluate the global, regional, and national trends of CMM among individuals aged 60 and elderly from 1990 to 2021. Methods: We retrieved data on the age-standardized incidence, prevalence, and mortality rates, and disability-adjusted life years (DALYs) of CMM among individuals aged 60 and above across 204 countries and territories from 1990 to 2021, sourced from the Global Burden of Disease (GBD), Injuries, and Risk Factors Study 2021. We calculated the estimated annual percentage changes in age-standardized incidence and DALY rates of CMM, categorized by age, sex, and socio-demographic index (SDI), to quantify temporal trends. Additionally, we employed Spearman correlation analysis to examine the relationship between age-standardized rates and SDI. Results: This study analyzed global trends in CMM from 1990 to 2021 using the GBD database. The findings indicate a significant increase in the incidence (EAPC=0.65, 95% CI: 0.33-0.96) and prevalence (EAPC=1.02, 95% CI: 0.64-1.41) of CMM, while a significant decreasing trend was observed for mortality (EAPC=-0.43, 95% CI: -0.57- -0.30) and DALYs (EAPC=-0.67, 95% CI: -0.82- -0.53). In 2021, high-income North America exhibited the highest prevalence of CMM but the lowest growth rate. In contrast, the Middle East and North Africa experienced the fastest growth rate, while Latin America also demonstrated a significant increase in prevalence. The growth rates of incidence and prevalence were notably higher among male patients compared to females, reflecting gender-specific behavioral differences. Furthermore, an analysis of the relationship between the burden of disease and the SDI for CMM across various regions from 1990 to 2021 revealed that the burden of disease in Australia significantly exceeded model predictions. The APC analysis indicated that the prevalence of CMM among elder population (≥60 years old) declined with age, but the overall disease burden continues to rise annually, demonstrating higher prevalence rates in later birth cohorts. Similar trends were observed for incidence, DALYs, and mortality. Conclusion: This study reveals that the burden of CMM disease is rapidly increasing among populations residing at lower latitudes. The findings underscore the necessity for dynamic optimization of global prevention and control strategies, considering regional disparities.
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