Evidence map›Paper›PMID 41425069›Full record

ArticleFrontiers in neuroscience2025

Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [

Prabesh Kanel, Stiven Roytman, Giulia Carli, Robert Vangel, Jaimie Barr, Fotini Michalakis, Christopher Chauncey Spears, Peter J H Scott, Roger L Albin, Nicolaas I Bohnen

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Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Prabesh KanelDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.
Stiven Roytman *Department of Radiology, University of Michigan, Ann Arbor, MI, United States.
Giulia CarliMorris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, United States.
Robert VangelDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.
Jaimie BarrDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.
Fotini MichalakisDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.
Christopher Chauncey SpearsDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.
Roger L AlbinMorris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, United States.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by a wide spectrum of motor and cognitive impairments. Structural brain imaging biomarkers, such as the Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0), are increasingly recognized as means of supporting a PSP diagnosis. These anatomic measures lack neurobiological correlates. In the present work, we investigated whether structural brain changes captured by MRPI 2.0 associate with whole-brain and regional cholinergic nerve terminal deficits in PSP. Methods: Structural magnetic resonance (MR) and vesicular acetylcholine transporter (VAChT) [ Results: Voxel-wise SPM analyses revealed that MRPI 2.0 is significantly associated with cholinergic nerve terminal loss in brainstem, especially pontomesencephalic, limbic structures, insula, basal ganglia, thalamus, and cerebellar regions. Discussion: Structural brain changes associated with higher MRPI 2.0 index scores may be a reliable proxy measure of cholinergic terminal deficits in PSP, predominantly those in subcortical regions. Differential association of subcortical brain region cholinergic deficits with PSP-specific structural brain changes may reflect the characteristic pattern of 4R-tau pathology observed in PSP.

Indexed as

FEOBVmidbrainMRPIPETprogressive supranucelar palsy

Identifiers

PMID41425069
PMCPMC12712803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.