ArticleFrontiers in neuroscience2025
Differentiating Fetal Alcohol Spectrum Disorder from other neurodevelopmental disorders: neurocognitive and socio-emotional evidence.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Increasing Access to FASD-Informed Care: Bringing an Adapted Intervention to Mental Health Providers.Evidence-based practice in child and adolescent mental health · 2026Article
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Authors and funding
11 authors.
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Abstract
Background: Fetal Alcohol Spectrum Disorder (FASD) is associated with widespread cognitive, behavioral, and adaptive impairments. Its clinical presentation often overlaps with other neurodevelopmental conditions (ND), such as learning disorders (LD) or Attention-Deficit/Hyperactivity Disorder (ADHD), making differential diagnosis challenging. Although syndrome-specific cognitive patterns have been suggested, a distinctive neurocognitive profile of FASD remains inconclusive. Method: Seventy-six children (46 with FASD and 30 with ND), aged 6-15 years ( Results: As compared to normative ranges, children with FASD felt below expected levels in cognitive functioning. Moreover, children with FASD showed significantly lower performance than those with ND across all cognitive domains, including global intelligence, verbal comprehension, working memory, processing speed, attention, memory, and executive functions. At the socio-emotional level, parental reports revealed that children with FASD scored higher than their peers with ND on anxiety, social and thought problems, attentional difficulties, and aggression behavior, although most of them remained within non-clinical ranges. Conclusion: Findings support the presence of a distinctive neurocognitive profile in FASD characterized by generalized cognitive deficits and domain-specific impairments (particularly in attention, memory, and executive functions). In addition, children with FASD scored higher on socio-emotional difficulties, although still within non-clinical ranges. These results highlight the clinical relevance of domain-specific assessment and underscore the need for early diagnosis and targeted evidence-based interventions to mitigate long-term cognitive and adaptive challenges associated with prenatal alcohol exposure.
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