ArticleIndian journal of sexually transmitted diseases and AIDS
Rapid growth of low-risk condyloma acuminata in an HIV-positive pregnant woman.
Article in Indian journal of sexually transmitted diseases and AIDS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Giant condyloma of Buschke-Lowenstein (GCBL) is a rare benign verrucous tumor, especially in women. It is primarily caused by human papillomavirus (HPV) types 6 and 11, with a preference for the anogenital area. Immunosuppressive conditions such as pregnancy and HIV infection can accelerate GCBL development due to hormonal changes and immune responses. A 28-week-pregnant HIV-positive woman (CD4 + count 235 cells/μl) who had not started antiretroviral therapy presented with a rapidly growing verrucous mass (20 cm × 7 cm × 2 cm) in the vaginal area extending to the anus, growing in 4 months. Diagnosis of GCBL was confirmed with HPV type 6. HPV, including low-risk types like 6 and 11, infects epithelial cells. Estrogen accelerates HPV gene expression in pregnant women, while HIV suppresses CD8 + T-cell activity and induces changes in the immune response. Increased regulatory T-cells (Treg) impair immune function, contributing to GCBL development. Pregnancy and HIV conditions can influence HPV infection progression to GCBL.
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