ArticleTherapeutic advances in gastroenterology2025
Emergence of amoxicillin resistance in refractory
Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study investigated temporal changes in resistance patterns among treatment-refractory Background: Antibiotic resistance in Design: We retrospectively analyzed adult patients at Linkou Chang Gung Memorial Hospital (2018-2024) with ⩾2 prior eradication failures and confirmed active infection via [13C]-urea breath test. Methods: Gastric biopsy specimens were cultured, and antimicrobial susceptibility testing was performed using the Epsilometer test for amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifabutin, ciprofloxacin, and moxifloxacin. Breakpoints were defined according to the European Committee on Antimicrobial Susceptibility Testing. Results: Among 144 patients (mean age 57.1 ± 10.8 years; 27.8% male), 88 were culture positive (61.1%), yielding 109 isolates. Resistance rates were high for clarithromycin (89.9%), levofloxacin (86.2%), metronidazole (71.6%), and ciprofloxacin (87.2%), while tetracycline resistance was 15.6%. A temporal trend analysis revealed a marked and statistically significant increase in amoxicillin resistance (odds ratio per year, 1.60; 95% confidence interval, 1.31-1.96; Conclusion: In refractory
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