ArticleFrontiers in bioinformatics2025
Uncovering human kinase substrates in nipah proteome.
Article in Frontiers in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Phosphoproteome-Entailed Kinase-Substrate Landscape of Human-DENV-2 Interaction.International journal of molecular sciences · 2026Article
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Authors and funding
12 authors.
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Abstract
Nipah virus (NiV) is a zoonotic pathogen that causes recurrent outbreaks with considerable implications for public health. Viruses engage host kinases to phosphorylate viral proteins, aiding replication and host disruption. Identifying NiV phosphoproteins and their host kinases is therefore critical for understanding the mechanism of infection and developing therapeutics. We performed kinase-substrate phosphomotif analysis based on prior studies and employed computational tools to identify putative phosphosites in NiV proteins and corresponding host kinases. Redundancy analysis highlighted key kinases capable of phosphorylating multiple NiV proteins and high-potential viral substrates. Integration with human-viral protein-protein interaction data revealed human kinase substrate proteins in human that interact with NiV proteins, while conservation analysis assessed phosphosites across nine NiV proteins in various strains. The functional significance of the identified and predicted viral substrates and their corresponding host kinases was further validated through
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