Evidence map›Paper›PMID 41424933›Full record

ArticleBlood neoplasia2025

Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell-mediated lysis and express targetable antigens.

Shannalee Martinez, Vladimir V Senyukov, Suheyla Hasgur, Arianexys Aquino-López, Peter D Emanuel, Y Lucy Liu, Elliot Stieglitz, Gregory Behbehani, Amanda R Campbell, Dean A Lee

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Article in Blood neoplasia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shannalee MartinezDepartment of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX.
Vladimir V SenyukovDepartment of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX.
Suheyla HasgurDivision of Hematology, Oncology, and Blood and Marrow Transplant, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH.
Arianexys Aquino-LópezDepartment of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX.
Peter D EmanuelWinthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR.
Y Lucy LiuWinthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR.
Elliot StieglitzDepartment of Pediatrics, Benioff Children's Hospitals, University of California San Francisco, San Francisco, CA.
Gregory BehbehaniDivision of Hematology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Amanda R CampbellDivision of Hematology, Oncology, and Blood and Marrow Transplant, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH.
Dean A LeeDivision of Hematology, Oncology, and Blood and Marrow Transplant, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm for which hematopoietic stem cell transplantation is the only curative treatment. Innovative therapies are needed to address high rates of morbidity, treatment-related mortality, and relapse. Monoclonal antibodies and adoptive cell transfer of natural killer (NK) cells or T cells are approved or being investigated for other myeloid leukemias; however, their activity against JMML warrants further investigation. In this study, we hypothesized that NK cells may effectively target JMML tumor cells. Mass cytometry was used to evaluate the expression of NK cell-activating and -inhibitory ligands and candidate target antigens on the monocytic and stem cell subsets of JMML. Monocytes from healthy donors and monocytic subsets of JMML were similar in NK cell ligand expression, and JMML monocytes were resistant to NK cell cytotoxicity in vitro. However, NK cells effectively controlled proliferation of JMML colony-forming cells. CD34

Identifiers

PMID41424933
PMCPMC12711676

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.