Evidence map›Paper›PMID 41424853›Full record

ArticleTheranostics2026

Development of New IL-1R Antagonists with Improved Anti-inflammatory Efficacy.

Mooseok Kang, Ae-Ree Lee, Hyeji Jung, Gyubin Jang, Byeongchan Kim, Sung-Hyun Yoon, Je-Wook Yu, Jaewon Ko, Ji Won Um, Iksoo Chang

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mooseok KangCytokine Innovation Center, iProtein Therapeutics Co. Ltd., Industry-University Cooperation Building R7-208, 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Ae-Ree LeeCytokine Innovation Center, iProtein Therapeutics Co. Ltd., Industry-University Cooperation Building R7-208, 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Hyeji JungDepartment of Brain Sciences, Daegu Gyeongbook Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Gyubin JangDepartment of Brain Sciences, Daegu Gyeongbook Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Byeongchan KimDepartment of Brain Sciences, Daegu Gyeongbook Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Sung-Hyun YoonDepartment of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Je-Wook YuDepartment of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Jaewon KoDepartment of Brain Sciences, Daegu Gyeongbook Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Ji Won UmDepartment of Brain Sciences, Daegu Gyeongbook Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.
Iksoo ChangCytokine Innovation Center, iProtein Therapeutics Co. Ltd., Industry-University Cooperation Building R7-208, 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Inflammatory AgentsInterleukin 1 Receptor Antagonist ProteinReceptors, Interleukin-1AnimalsCell LineDisease Models, AnimalHumansInterleukin-1betaMiceMice, Inbred C57BLMicrogliaMolecular Dynamics SimulationNeuroinflammatory DiseasesNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinAnti-Inflammatory AgentsInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Interleukin-1anakinraantagonistanti-inflammatory efficacybinding free energyinflammationin silico protein designinterleukin-1interleukin-1 receptorInterleukin-1βinterleukin-6molecular dynamics simulationsthermodynamic integration

Identifiers

PMID41424853
PMCPMC12712897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.