Evidence map›Paper›PMID 41424839›Full record

ArticleTheranostics2026

Lipid nanoparticle-formulated DNA acts as a potent immune modulator for cancer immunotherapy through interferon signaling pathways.

Chen-Yi Chiang, Ming-Shu Hsieh, Mei-Yu Chen, Yu-Wen Tsai, Chang-Ling Lin, Chia-Wei Hsu, Guann-Yi Yu, Ming-Hsi Huang, Shih-Jen Liu, Hsin-Wei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chen-Yi ChiangNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Ming-Shu HsiehNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Mei-Yu ChenNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Yu-Wen TsaiNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Chang-Ling LinNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Chia-Wei HsuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Guann-Yi YuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Ming-Hsi HuangNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Shih-Jen LiuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Hsin-Wei ChenNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNAImmunologic FactorsImmunotherapyInterferonsLipidsNanoparticlesNeoplasmsSignal TransductionAnimalsDisease Models, AnimalFemaleLiposomesMiceMice, Inbred C57BLMice, KnockoutPlasmidsDNAImmunologic FactorsInterferonsLipid NanoparticlesLipidsLiposomesToll-Like Receptor 9immunotherapyinflammatory responseslipid nanoparticlesplasmid DNAtumor microenvironments

Identifiers

PMID41424839
PMCPMC12712898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.