ArticleJAR life2025
The associations between pretreatment neutrophil-to-lymphocyte ratio, sarcopenia and frailty in older patients with head and neck cancer.
Article in JAR life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neutrophil percentage-to-albumin ratio is associated with low muscle mass risk in rheumatoid arthritis: evidence from a hospital-based cohort and NHANES validation.Frontiers in immunology · 2026Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Performing a Geriatric Assessment (GA) is recommended to help guiding treatment decisions in vulnerable older patients. As a full GA is time consuming and expensive, frailty screening methods are worth investigating. Sarcopenia and the neutrophil-to-lymphocyte ratio (NLR) could be easily available biomarkers related to frailty. Objectives: We investigated the relationships between NLR, sarcopenia, and frailty, and assessed the potential of NLR as a frailty screening method in older patients with head and neck cancer (HNC). In addition, the relationship between the NLR and each GA item was investigated. Design: Retrospective study. Participants and Measurements: 148 older (≥ 60 years) patients with HNC who had undergone pretreatment a GA, routine blood sample, handgrip strength (HGS) and head and neck CT or MRI for skeletal muscle mass measurement (SMM). The GA to determine frailty was assessed as outcome. Sarcopenia was defined as the combination of low SMM and low HGS. Results: The mean age was 70 (6.08 SD) years. A total of 95 (64 %) patients had an elevated NLR and 21 (14 %) had sarcopenia. Based on the GA, 56 (38 %) patients were determined as frail. Patients with an elevated NLR were more likely to be frail and sarcopenic compared to patients with a normal NLR. NLR score showed a significant though weak correlation with frailty ( Conclusion: Increased NLR is frequently observed in older HNC patients, often in combination with low SMI and frailty. There is a significant correlation between NLR and frailty. However, the accuracy of NLR to predict frailty based on GA is limited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.