Evidence map›Paper›PMID 41424789›Full record

ArticleFrontiers in pharmacology2025

Case Report: Exercise-associated changes of leukocyte gene expression in statin-associated myopathy.

Galyna Bondar, Abhinandan Das Mahapatra, Irina Silacheva, Tra-Mi Bao, Thomas Vu, Stephanie Su, Adrian Hairapetian, Ananya Katappagari, Liana Galan, Joshua Chandran and 16 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Galyna BondarDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Abhinandan Das MahapatraAssociate Bioinformatics Engineer III, Organization: Strand NGS, Strand Life Sciences Pvt. Ltd., Bengaluru, India.
Irina SilachevaDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Tra-Mi BaoDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Thomas VuDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Stephanie SuDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Adrian HairapetianDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Ananya KatappagariDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Liana GalanDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Joshua ChandranDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Ruben AdamovDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Alan YangDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Ananya BukkapatnamDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Pejman MansouriDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Mahi MirchandaniDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Nathan DangDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Lorenzo MancusiDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Isabel LaiDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Anca RahmanDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Tristan GroganDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Jeffrey HsuDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Monica CappellettiDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
PeiPei PingDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
David ElashoffDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Elaine F ReedDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.
Mario C DengDavid Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Statin-associated muscle symptoms (SAMS) are a significant clinical issue, and their exact cause is not well understood. Immunological mechanisms have been suggested but have not been confirmed. This study is a rare, longitudinal case-based analysis that uses transcriptomics to explore immune-related gene expression changes in peripheral blood mononuclear cells (PBMCs) in response to exercise before, during, and after the onset and resolution of SAMS. Methods: A healthy volunteer (HV1) enrolled in an exercise immuno-fitness study underwent cardiopulmonary exercise testing (CPX) with blood collected at three timepoints: pre-exercise (TP1), peak exercise (TP2), and 1 hour post-exercise (TP3). After baseline testing (Visit 1), the participant began statin therapy on their own, developed SAMS, and had repeat CPX testing during the symptomatic phase (Visit 2) and partial recovery phase (Visit 3). RNA was extracted from PBMCs and analyzed using next-generation RNA sequencing. The data were evaluated using differential gene expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA). Pathway and gene ontology enrichment were used to identify immunologic signatures associated with SAMS. Results: The PBMC gene expression profiles showed distinct changes during SAMS compared to the baseline and recovery phases. WGCNA identified 39 co-expression modules. Several modules had high expression at peak exercise in the healthy state (V1), which was attenuated in SAMS (V2) and partially restored in recovery (V3). Gene ontology and Reactome analyses of key modules identified 16 genes that were differentially expressed at peak exercise and may be involved in specific immune pathways in SAMS pathogenesis. Conclusion: This case study suggests that profiling the exercise-induced immune transcriptome can reveal dynamic immunological changes related to statin-induced myopathy. These findings support the hypothesis of an immune-mediated component in SAMS and provide a basis for future studies to validate transcriptomic biomarkers for the early detection and management of SAMS.

Indexed as

exercise-associated changesimmunological fitnessperipheral blood mononuclear cell transcriptome profilingstatin-associated adverse effectsstatin-associated myopathystatin-myopathy

Identifiers

PMID41424789
PMCPMC12713417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.