ArticleNAR genomics and bioinformatics2025
rDNAcaller: a fast and robust pipeline to call ribosomal DNA variants.
Article in NAR genomics and bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Germline sequence variation within the ribosomal DNA is associated with human complex traits.Cell genomics · 2026Article
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9 authors.
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Abstract
Ribosomal DNA (rDNA) is arranged in tandem repeats in the human genome. Extensive genetic and copy number variation in rDNA has been reported both within and between individuals, contributing to phenotypic diversity. However, traditional variant callers, designed for diploid regions, have not been systematically benchmarked for analyzing rDNA. We developed a customized simulator that replicates real intra- and inter-individual rDNA variation to benchmark the performance of commonly used variant callers, including GATK, Mutect2, and Lofreq*. Additionally, we optimized the preprocessing and mapping steps to significantly improve accuracy. Based on these optimizations, we introduce
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