Evidence map›Paper›PMID 41424711›Full record

ArticlePeerJ2025

Exosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network.

Zhenglei Shen, Honghua Cao, Yeying Zhou, Wenwen Mao, Kunmei Liu, Jingying Zhu, Ming He, Yunru Mao, Ni Luo, Lei Feng and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhenglei Shen *Department of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Honghua Cao *Department of Hematology, Longhua District People's Hospital, Shenzhen, China.
Yeying ZhouDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Wenwen MaoDepartment of Geriatics, The Second Hospital of Kunming, Kunming, China.
Kunmei LiuDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Jingying ZhuNO.1 Head and Neck External Department, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Ming HeDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Yunru MaoNo.10 Middle School, Kunming, China.
Ni LuoDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Lei FengDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Heng LeDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Liying SongDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
HuaXian LiDepartment of Hematology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Yasar Mehmood YousafzaiInstitute of Pathology and Diagnostic Medicine Khyber Medical University, Peshawar, Pakistan.
Asad ZiaMolecular Biologist Public Health Reference Laboratory, Peshawar, Pakistan.
Xuezhong GuDepartment of Hematology, The First People Hospital in Yunnan Province, Kunming, China.
Shiwen ZhangNO.1 Head and Neck External Department, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic myeloid leukemia (CML) progression relies on dynamic crosstalk between leukemic cells and vascular niches. Here, we investigate how exosomes and BCR/ABL overexpression influence endothelial functions, aiming to identify key mediators of leukemia-induced microenvironmental remodeling as potential therapeutic targets. Methods: Human umbilical vein endothelial cells (HUVECs) were cultured and divided into four groups: control (Z), treated with K562-derived exosomes (Zexo), BCR-ABL-overexpressing (ZBA), and BCR-ABL-overexpressing with exosome treatment (ZBAexo). Transcriptomic profiling was performed to identify DEGs, followed by functional enrichment and protein-protein interaction network analyses. Gene Set Enrichment Analysis (GSEA) was applied to uncover associated biological pathways. Results: Seven specificized expressed genes in ZBAexo group were identified: Conclusion: This study identifies seven novel candidate biomarkers dysregulated in endothelial cells under combined BCR-ABL and exosomal stimulation, shedding light on the molecular crosstalk between leukemic cells and the vascular niche.

Indexed as

ExosomesFusion Proteins, bcr-ablGene Regulatory NetworksLeukemia, Myelogenous, Chronic, BCR-ABL PositiveGene Expression ProfilingGene Expression Regulation, LeukemicHumansHuman Umbilical Vein Endothelial CellsK562 CellsProtein Interaction MapsFusion Proteins, bcr-ablBiomarkersChronic myeloid leukemia (CML)ExosomesHuman umbilical vein endothelial cells(HUVECs)K562 cell line

Identifiers

PMID41424711
PMCPMC12717845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.