ArticleHealth science reports2025
Evaluation of the Association of TNF-α rs361525 Gene Polymorphism in Bangladeshi Patients With Breast and Cervical Cancer: A Case-Control Study and Meta-Analysis.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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11 authors.
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Abstract
Background and Aims: Incidence and fatality rates are highest for breast cancer (BC) and cervical cancer (CC), making them the most prevalent types of cancer. Prior research has documented certain cytokines, such as tumor necrosis factor-alpha (TNF-α), as being accountable for the growth and advancement of these cancerous conditions. To assess the possible association, we examined the correlation between the TNF-α rs361525 polymorphism (-238 G > A) and the susceptibility to both BC and CC. Methods: A case-control study was conducted on a total of 155 BC patients, 157 CC patients, and 150 controls. The genotyping process utilized the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. To ascertain the extent of the risk association of rs361525, we assessed the Results: In terms of TNF-α rs361525 polymorphism, the GA genotype (OR = 0.42, Conclusion: In summary, our research demonstrated that the rs361525 gene polymorphism in the TNF-α locus may possess a protective effect against BC and CC in the Bangladeshi population. Furthermore, the meta-analysis results suggested no link between rs361525 polymorphism and BC. We suggest carrying out future studies with a larger sample size on the other ethnic population and cutting-edge genotyping technologies to obtain comprehensive and precise outcomes.
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