ReviewRegenerative therapy2025
Innovative tissue engineering strategies for auricular regeneration in microtia: Current advances and future perspectives.
Review in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Auricular cartilage tissue engineering: from making cartilage to regenerating a shape-stable elastic organ.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtia is a congenital auricular malformation that typically requires reconstructive surgery to restore both form and function. Autologous costal cartilage transplantation remains the clinical standard, yet its invasiveness and donor-site morbidity have driven growing interest in tissue-engineered alternatives. Modern cartilage tissue engineering integrates seed cells, biomaterial scaffolds, and bioactive factors, augmented by emerging technologies such as 3D printing, electrospinning, and dynamic bioreactors. This review summarizes recent progress in auricular reconstruction, with a focus on multilayer scaffold design, diverse cell sources, and advanced bioreactor systems. We emphasize the pivotal role of multi-omics technologies in elucidating the molecular mechanisms underlying chondrogenesis. However, despite substantial progress, clinical translation remains hindered by persistent challenges in replicating the complex architecture of the auricle and achieving long-term stability of engineered cartilage. Optimizing tissue engineering strategies and integrating regenerative medicine with surgical practice may help advance clinical outcomes in microtia treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.