ArticleFrontiers in sleep2024
Cardiopulmonary coupling-calculated sleep stability and nocturnal heart rate kinetics as a potential indicator for cardiovascular health: a relationship with blood pressure dipping.
Article in Frontiers in sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01086800 (Phase II Trial of Sleep Apnea Treatment to Reduce Cardiovascular Morbidity), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II Trial of Sleep Apnea Treatment to Reduce Cardiovascular Morbidity
Who cites it
2 citing papers in PubMed.
- Cross-sectional associations between actigraphy-measured sleep and 24-h ambulatory blood pressure phenotypes among self-reported short sleepers with elevated blood pressure.Sleep medicine · 2026Article
- A chamber study of respiratory and autonomic responses to hydrotreated vegetable oil exhaust using ECG-derived respiration.Frontiers in physiology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: High blood pressure (HBP) is an independent, modifiable driver of cardiovascular (CV) morbidity and mortality. Nocturnal hypertension and non-dipping of blood pressure (NdBP) may be early markers of HBP. Similar to patients with NdBP, individuals with non-dipping of heart rate (NdHR) during sleep have an increased risk of CV disease, CV events, and CV-related mortality. The aim of this analysis was to evaluate if cardiopulmonary coupling (CPC) analysis-derived sleep states [stable/unstable non-rapid eye movement (NREM) sleep] and concomitant heart rate (HR) changes can provide information about nocturnal blood pressure (BP). Method: Plethysmogram (pleth) signals from the HeartBEAT study (NCT01086800) were analyzed for CPC sleep states. Included in the analysis are sleep recordings from participants with acceptable pleth-signal quality at baseline ( Results: The most significant difference in minimum HR (HR Conclusion: HR analytics in relation to the sleep period and the CPC spectrogram-estimated sleep states can provide novel and potentially clinically useful information on autonomic health. HR dipping (or not) may be a useful screener of BP dipping or non-dipping to identify individuals who may benefit from a formal assessment of 24-h ambulatory BP. Such a stepped approach may enable a more practical and applicable approach to diagnosing HBP. Clinical Trial Registration: The Heart Biomarker Evaluation in Apnea Treatment (HeartBEAT) study is registered at clinicaltrials.gov/ct2/show/NCT01086800.
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Registered trials
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