ReviewFrontiers in chemistry2025
Advances in smart stimuli-responsive materials for oral wound healing.
Review in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- The role of bioactive molecules in enhancing bone healing in oral and maxillofacial surgery: a review of current approaches and future directions.Oral and maxillofacial surgery · 2026Review
- Recent Advances in Microenvironment-Responsive Materials for Periodontitis Therapy.International journal of molecular sciences · 2026Review
- Smart microdevices for biomedical drug delivery: endogenous stimuli as the key to safer therapeutics.RSC advances · 2026Review
- Biomaterial strategies for precision regeneration of the tooth extraction socket: integrating site phenotype, pathological microenvironment, and healing sequence.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral wounds, particularly those coupled with bone defects like osteoradionecrosis and periodontitis, present a profound clinical challenge. While conventional biomaterial dressings offer basic therapeutic benefits, their static nature hinders dynamic interaction with the complex wound microenvironment, where factors like fluctuating pH and enzymatic activity impair healing. This review focuses on the development of "smart" stimuli-responsive dressings that overcome this limitation. These advanced systems are engineered to sense specific intraoral signals, such as pH, reactive oxygen species, or enzymes, or external triggers like light, enabling on-demand drug release and active wound microenvironment reprogramming. We critically synthesize recent progress in their design, stimuli-responsive mechanisms and therapeutic application, with a dedicated emphasis on bone-related oral pathologies. Furthermore, the review addresses the critical translational challenges and future prospects for bridging material innovation with clinical needs, aiming to facilitate next-generation regenerative therapies for oral and craniofacial defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.