ArticleUlusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES2025
A new score for predicting incidental appendiceal neoplasms in patients aged ≥40 years with acute appendicitis: a multicenter retrospective cohort study.
Article in Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis multicenter retrospective cohort study aimed to develop a novel five-parameter scoring model to predict incidental appendiceal neoplasia in patients aged ≥40 years diagnosed with acute appendicitis. Previous literature has reported a significant increase in the risk of neoplasia, particularly after age 40, and this cut-off value was used as the basis for our study design.
methodsA multicenter retrospective cohort analysis was conducted across six tertiary hospitals between January 2019 and December 2024. Adult patients aged ≥40 years who underwent appendectomy with preoperative contrast-enhanced computed tomography (CT) and had available laboratory data were included. Predictive variables were identified using multivariate logistic regression. The scoring system incorporated age, female sex, appendix diameter, absence of CT wall enhancement, and low neutrophil count. Diagnostic performance was assessed via receiver operating characteristic (ROC) analysis.
resultsOf 2,143 patients analyzed, 122 (5.7%) had incidental neoplasia. The scoring system yielded an area under the ROC curve of 0.641 (95% confidence interval: 0.594-0.690). Using a cutoff score ≥3, sensitivity was 56.6%, specificity 65.4%, positive predictive value 9%, and negative predictive value 96.1%. Patients with a maximum score of 5 had a 33.3% incidence of neoplasia.
conclusionThis five-parameter scoring system demonstrates a high negative predictive value and may help identify low-risk patients in whom standard appendectomy can be safely performed. This model, which allows low-risk patients to be safely excluded thanks to its high negative predictive value, provides an innovative contribution to clinical decision-support systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.