Evidence map›Paper›PMID 41424194›Full record

ArticleBrain pathology (Zurich, Switzerland)2026

Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction.

Shelby C Osburn, Darby S Easterday, Cali M McEntee, Amanda S Latham, Daniel S Lark, Stephanie McGrath, Julie A Moreno, Thomas J LaRocca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shelby C OsburnDepartment of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Darby S EasterdayDepartment of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Cali M McEnteeDepartment of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Amanda S LathamDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0003-1402-2801
Daniel S LarkDepartment of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Stephanie McGrathBrain Research Center, Colorado State University, Fort Collins, Colorado, USA.
Julie A MorenoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-9618-2712
Thomas J LaRoccaDepartment of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.

Funding

Age-related repetitive element dysregulation, neuroinflammation and Alzheimer's diseaseR01AG078859 · NIA · COLORADO STATE UNIVERSITY · PI Thomas LaRocca · 2022 to 2026
$1.9M
Role of age-dependent repetitive element transcript dysregulation in Alzheimers diseaseR03AG070562 · NIA · COLORADO STATE UNIVERSITY · PI LAROCCA, THOMAS · 2021 to 2022
$304k
NIA NIH HHS AG060302NIA NIH HHS AG070562NIA NIH HHS AG073137NIA NIH HHS AG078859NIA NIH HHS R01 AG078859NIA NIH HHS R03 AG070562
6 · The paper itself

Abstract

Growing data suggest companion dogs may be a promising model of human brain aging and Alzheimer's disease (AD). However, although pathology is somewhat similar in canine cognitive dysfunction (CCD) and AD, the transcriptomic similarities between these two conditions have not been thoroughly evaluated. Two emerging transcriptome-related mechanisms of human brain aging and AD involve transposable elements (TEs) and microRNAs (miRNAs), which have the potential to be carried systemically and between cells by extracellular vesicles (EVs). To determine if evidence of these AD-related transcriptomic events might be present in CCD, we generated transcriptome (RNA-seq) data on prefrontal cortex tissue and plasma EVs from young, older, and older CCD dogs. We show that: (1) global transcriptome changes with CCD indicate reduced neuronal health; (2) TE transcripts increase with CCD in both the brain and plasma EVs; (3) brain- and disease-relevant miRNAs are present in the same EVs, and some of these miRNAs correlate with indices of cognitive function/CCD. Collectively, our data suggest that transcriptomic changes in CCD, including those related to novel RNA mechanisms of brain aging and AD, may be similar to those observed in humans.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDog DiseasesTranscriptomeAgingAnimalsBrainDisease Models, AnimalDogsExtracellular VesiclesFemaleHumansMaleMicroRNAsMicroRNAsagingAlzheimer's diseasebraintranscriptomicstranslational models

Identifiers

PMID41424194
PMCPMC13051885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.