Evidence map›Paper›PMID 41423957›Full record

ArticleBiomolecules & therapeutics2026

Targeting YAP-TEAD Interaction with Honokiol to Inhibit Melanoma Progression and Metastasis.

Chaelin Lee, Hien Thi Thu Do, Xiang Fei, Sanha Lee, Soonsil Hyun, Seung-Yong Seo, Inmoo Rhee

Abstract read
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In one paragraph

Article in Biomolecules & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chaelin LeeDepartment of Biotechnology and Bioscience, Sejong University, Seoul 05006, Republic of Korea.
Hien Thi Thu DoDepartment of Biotechnology and Bioscience, Sejong University, Seoul 05006, Republic of Korea.
Xiang FeiCollege of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
Sanha LeeCollege of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
Soonsil HyunCollege of Pharmacy, Chungbuk National University, Cheongju 28460, Republic of Korea.
Seung-Yong SeoCollege of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
Inmoo RheeDepartment of Biotechnology and Bioscience, Sejong University, Seoul 05006, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Hippo-YAP/TEAD pathway plays a central role in melanoma progression by regulating tumor cell proliferation, survival, and migration. Using a NanoLuc Binary Technology (NanoBiT) protein-protein interaction assay, we screened honokiol-based small molecules and identified several analogues that disrupt the YAP-TEAD interaction. HK03 was the most effective analogue, leading to a pronounced reduction in Cyr61 levels and diminished Erk and Akt phosphorylation in B16-F10 melanoma cells. HK03 also blocked epithelial-mesenchymal transition (EMT) and impaired melanoma cell migration in wound-healing assays.

Indexed as

Cyr61Hippo signaling pathwayHonokiolMelanomaYAP-TEAD

Identifiers

PMID41423957
PMCPMC12782857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.