ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Selective methylation is among the most relevant transformations in synthetic chemistry and the discovery of new drug molecules. A methyl group is typically installed using strong electrophiles such as methyl iodide or dimethyl sulfate, which are associated with safety hazards and limited chemoselectivity. A promising strategy for circumventing these limitations relies on splitting the methylation into a two-step procedure under mediator control. However, such reactions, including the Mukaiyama redox condensation, currently lack applicability since the mediator is lost as organic waste, resulting in a low atom economy. We have developed a flavin-mediated methylation strategy with easily accessible methyl diphenylphosphinite (Ph
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.