ArticleJournal of the American Chemical Society2026
Merging Enzymatic Catalysis with Iron Catalysis for Highly Stereoselective Heparan Sulfate Oligosaccharide Assembly.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans.Current opinion in chemical biology · 2026Review
- Process Safety Assessment of the Iron-Catalyzed 1,2-Organic process research & development · 2026Article
- Iron Porphyrin Catalysts Induce Stereospecific Glycosylation with Glycal Epoxides.Synlett : accounts and rapid communications in synthetic organic chemistry · 2026Article
- Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides.Organic letters · 2026Article
- Process Safety Assessment of the Iron-Catalyzed 1,2-Research square · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Heparan sulfate (HS) regulates numerous biological processes, but it occurs naturally as a heterogeneous mixture of sulfated complex glycans. Therefore, pursuing a broadly effective approach for homogeneous HS synthesis to advance biological studies has been an outstanding challenge in glycoscience. By merging the catalytic power of sulfotransferases (SULTs) with two distinct iron-catalyzed glycosylation reactions, we report herein a highly stereoselective and generally applicable HS assembly strategy. Every glycosidic linkage in HS was assembled by one of these iron-catalyzed, entirely stereoselective glycosylation reactions. An array of sulfate groups that are essential to HS's function were installed at their desired locations via the SULT-controlled sulfation of HS precursors. This general approach is showcased in the synthesis of an anticoagulant HS hexasaccharide and other full-length precursors of HS octasaccharides.
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