ArticleAngewandte Chemie (International ed. in English)2026
Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme.Chemical science · 2026Article
- Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Organofluorine compounds are vital in pharmaceuticals, and enzymes, nature's most efficient catalysts, offer tremendous potential for precise fluorination. However, no enzymatic strategies for intermolecular C-H fluorination have been realized-until now. We present the first radical photoenzymatic system enabling intermolecular C-H fluorination using an unnatural amino acid within a robust de novo protein scaffold. This system achieves chemoselective benzylic monofluorination in aqueous solutions with Selectfluor, driven by hydrogen atom transfer from the photoexcited amino acid. It successfully fluorinated various aromatic compounds and enabled biosynthesis of fluorinated polyketides and chiral fluorinated alcohols. These results establish radical photoenzymatic systems as a powerful new approach for efficient, selective biocatalytic fluorination, with direct relevance to pharmaceuticals.
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