Trial reportJournal of cosmetic dermatology2025
Assessment of Hyaluronic Acid Filler in Gluteal Augmentation and Contouring: A 1-Year Prospective Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinimally invasive gluteal augmentation techniques have gained popularity as alternatives to surgical procedures, offering reduced downtime and an improved safety profile. Hyaluronic acid (HA) fillers have emerged as a promising option due to their biocompatibility and favorable rheological characteristics.
objectivesTo evaluate safety, efficacy, durability, and patient satisfaction of a cross-linked HA filler for gluteal augmentation and contouring over a 12-month period, and to conduct a pilot exploratory substudy assessing serum HA levels up to 90 days.
methodsThis was a 12-month, prospective, multicenter, open-label study including 30 healthy women undergoing gluteal augmentation with a cross-linked HA filler (UP Max). Each participant received up to 60 mL of HA filler, administered using a quadrant-based technique, guided by anatomical landmarks. Outcomes included safety (adverse events), efficacy (standardized photography and 3D imaging, ultrasound), durability and patient satisfaction. In addition, serum HA levels were measured in a pilot subgroup of patients.
resultsThe mean injected volume was 43.60 ± 11.48 mL. Patient satisfaction peaked at Day 30 (90%) and declined to 62% at 12 months, consistent with HA biodegradation. Ultrasound confirmed subcutaneous placement and progressive filler absorption and integration, with no signs of migration, fibrosis or nodularity. Serum HA levels showed a transient increase at Day 30 and returned to near baseline at Day 90. No serious adverse events were reported, and minor complications were infrequent.
conclusionsHA filler demonstrated a favorable safety profile, high patient satisfaction, and aesthetic improvements over 1 year. These findings support its use as a safe and effective option for nonsurgical gluteal augmentation and body contouring.
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