Evidence map›Paper›PMID 41423687›Full record

ArticleEnvironmental microbiome2025

Plant-microbiome interactions suppress Fusarium wilt by enriching beneficial Aspergillus in the tobacco rhizosphere.

Shuang Han, Yang Yang, Senqi Xiong, Hao Zheng, Min Yan, Yide Yang, Sai Guo, Hongjun Liu, Jiangang Li, Jie Yin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Combined effects of earthworms andFrontiers in microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuang Han *Sanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Yang Yang *Yibin Branch of Sichuan Province Tobacco Company, Yibin, 644600, Sichuan, China.
Senqi XiongSanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Hao ZhengSanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Min YanYibin Branch of Sichuan Province Tobacco Company, Yibin, 644600, Sichuan, China.
Yide YangYibin Branch of Sichuan Province Tobacco Company, Yibin, 644600, Sichuan, China.
Sai GuoSanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Hongjun LiuSanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Jiangang LiState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 211135, China. jgli@issas.ac.cn.
Jie YinYibin Branch of Sichuan Province Tobacco Company, Yibin, 644600, Sichuan, China. 565125441@qq.com.
Rong LiSanya Institute of Nanjing Agricultural University, Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Technology Innovation Center of Hainan Province, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China. lirong@njau.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities KTTQ2025018the Priority Academic Program Development of the Jiangsu Higher Education Institutions PAPDthe Science and Technology Project of Sichuan Branch of China National Tobacco Corporation SCYC202304
6 · The paper itself

Abstract

backgroundTobacco (Nicotiana tabacum) is a globally significant economic crop with a production that is severely threatened by soil-borne fungal pathogens, particularly Fusarium spp. Native rhizosphere microbial communities, especially those of root-associated fungi, have been suggested as sustainable solutions for disease suppression. However, the compositional differences in root-associated fungal communities between healthy and diseased tobacco plants remain poorly characterized.

resultsIn this study, we investigated the root-associated fungal communities in healthy versus Fusarium-infected tobacco plants across three geographically distinct fields in Sichuan Province, China, to identify key microbial taxa involved in disease suppression. High-throughput sequencing revealed distinct fungal community compositions among the sites. The healthy rhizospheres were enriched with beneficial taxa, among which Aspergillus OTU2223 was the most dominant and potentially crucial for disease suppression. In contrast, diseased soils were dominated by pathogenic Fusarium taxa, with Fusarium solani being the most prevalent pathogen. Network analysis revealed that, compared with diseased soils, healthy rhizospheres maintained a greater number of nodes (306 vs. 282) and higher modularity (0.46 vs. 0.31) microbial interactions. We isolated and characterized Aspergillus strain A74, which demonstrated strong antagonistic activity against F. solani f. sp. nicotianae both in vitro and in greenhouse trials, thereby reducing the incidence of Fusarium wilt disease in greenhouse trials. The application of strain A74 maintained the growth parameters (including height, stem diameter, and chlorophyll content) of pathogen-inoculated plants at levels comparable to healthy plants.

conclusionIn summary, our study demonstrated that healthy tobacco plants assemble distinct root-associated fungal communities characterized by beneficial Aspergillus taxa that exhibit exceptional potential as biocontrol agents. These findings provide a theoretical foundation and practical support for the development of Aspergillus-based green biocontrol strategies, highlighting their potential as an environmentally friendly and sustainable approach to disease management in tobacco production.

Indexed as

Aspergillus spp.Disease suppressionFusarium wilt of tobacco

Identifiers

PMID41423687
PMCPMC12750933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.