Trial reportScientific reports2025
Intense pulsed light treatment improved tear film quality and reduced ocular surface inflammation in dry eye patients.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the tear levels of Lymphotoxin-alpha (LT-α) and the clinical efficacy of intense pulsed light (IPL) treatment in patients with dry eye disease (DED). This randomized study included 28 participants with DED who received 3 IPL therapies at Week 0 (Baseline), Week 3(3W), and Week 6(6W) (N = 30 eyes), or 2 IPL therapies at Baseline, 3W and a sham IPL therapy at 6W (N = 26 eyes). All participants were examined at Baseline, 3W, 6W, Week 9(9W), and Week 12(12W) for non-invasive break-up time (NITBUT), LT-α, meibomian gland quality (MGQ), tear meniscus height (TMH), conjunctivocorneal staining score (CFS), meibomian gland expression (MGEx), tear-film lipid layer (TFLL), and ocular surface disease index (OSDI). Baseline measures exhibited no significant differences between the groups (all p > 0.05). At 6W, NITBUT, MGEx, CFS, and OSDI were significantly improved compared with the Baseline (p < 0.05). At 12W, a comparison between the 3 IPL therapy group and 2 IPL therapy group found significant improvements in the NITBUT (p = 0.002), TMH (p = 0.011), TFLL (p = 0.009), MGEx (p = 0.011), MGQ (p = 0.021), LT-α (p = 0.034), while the CFS (p = 0.104), OSDI (p = 0.189) had no significant improvements. IPL treatment can improve the clinical symptoms and signs of DED. The potential long-term benefit of 3 IPL treatments is better than 2 treatments.Trial registration: ClinicalTrials.gov, TRN: NCT0626923, Registration date: 21 February 2024.
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