ArticleCritical care (London, England)2025
Airway opening pressure in mechanically ventilated patients: regional distribution and impact of body position.
Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The impact of head and thorax elevation on respiratory mechanics during cardiopulmonary resuscitation: a multi-model study.Resuscitation plus · 2026Article
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway Opening Pressure (AOP) refers to the pressure level needed to reopen previously collapsed airways. Its underlying mechanisms remain debated. This study aimed to assess its regional distribution and the effect of body position.
methodsGlobal AOP (AOPGLOBAL) was assessed by the low-flow inflation maneuver. Electrical impedance tomography allowed to assess regional AOP (ventral and dorsal). Measurements were performed in the semi-recumbent position (SR30°) in all patients and repeated in supine position (SP0°) in a subgroup of patients to explore the effect of body position. As a proof of concept, AOP was also evaluated in four Thiel cadavers in both SR30° and SP0°, with and without the adjunction of a 3 kg saline bag on the abdomen.
results46 mechanically ventilated patients were analyzed. In SR30°, AOPGLOBAL was detected in 10 patients (22%) (median level 8.4 [6.3–12.0] cmH2O), while AOPVENTRAL and AOPDORSAL occurred in 11 (24%) and 16 (35%) patients, respectively. The lowest regional AOP correlated with the AOPGLOBAL (r2 = 0.993, p < 0.001). In the subgroup of 23 patients with position analysis, the highest regional AOP increased from SR30° to SP0°. Cadavers’ experiments showed that the increase in end-expiratory esophageal pressure associated with SP0° or increased abdominal pressure correlated with the increase in AOPGLOBAL (r2 = 0.908, p < 0.001).
conclusionBedside AOP detection based on the low-flow insufflation method may miss regional AOP, leading to an underestimation of the minimal positive end-expiratory pressure which may be required to avoid tidal opening and closing in some lung regions. The level of regional AOP increases in SP0° compared to SR30° position.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.