ArticleClinical oral investigations2025
A new method for continuous in vivo pH measurement in saliva and oral biofilm - a comparative pilot study.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMeasuring intraoral pH is a factor in determining the pathogenicity of processes. Until now, been continuous pH measurement over a period of 96 h in parallel (saliva [S]) and established biofilm [B]) has not been feasible. This exploratory study aimed to develop a method for continuous, wireless pH monitoring of both S and B.
methodsA wireless device with integrated pH probes was used to measure SpH and BpH in 12 participants (average age 24.28 ± 2.77 years) over a period of 96 h. Participants drank a glucose solution at three specified measurement points (G0: Baseline, G1: Glucose decline, G2: 30 min after drinking) and the 24-hour periods within the 96-hour measurement period were evaluated. The device was removed during meals and while brushing teeth.
resultsGlucose intake significantly reduced pH in both (S + B) (p < 0.001). SpH was significantly higher (G0/ G1/ G2: 6.29 ± 0.29/ 5.55 ± 0.33/ 5.79 ± 0.32) than in BpH (G0/ G1/ G2: 6.03 ± 0.33/ 5.34 ± 0.41/ G2: 5.56 ± 0.32) at all three selected measurement points (p-value at G0/ G1/ G2: p = 0.003/ p = 0.005/ p = 0.002). Regardless of glucose intake, no statistical difference was found between SpH (0–24 h/ 24–48 h/ 48–72 h/ 72–96 h: 5.86 ± 0.41/ 5.75 ± 0.37/ 5.92 ± 0.38/ 5.90 ± 0.31), BpH (5.60 ± 0.52/ 5.59 ± 0.29/ 5.77 ± 0.39/ 5.70 ± 0.46) in the time periods (p-value 0–24 h/ 24–48 h/ 48–72 h/ 72–96 h: p = 0.09/ p = 0.27/ p = 0.40/ p = 0.27).
conclusionsThe study design offers the possibility to continuously measure the pH value in S and B in the oral cavity over a period of 96 h. CLINICAL RELEVANCE: This wireless method developed for measuring pH in S and B can collect data under everyday conditions and has the potential to become a patient-friendly approach for pH monitoring in the future.
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