Evidence map›Paper›PMID 41423554›Full record

ArticleExperimental & molecular medicine2025

METTL3/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis.

Ning Huangfu, Fang Li, Chenqiu Wang, Shouyi Jin, Xiaoya Zheng, Yingsong Wang, Tianxiang Fang, Jiaxi Shen, Yanan Yu, Liguo Jian and 3 more

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. mFrontiers in immunology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ning Huangfu *Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Fang Li *Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chenqiu Wang *Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shouyi JinDepartment of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoya ZhengDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Yingsong WangDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Tianxiang FangDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Jiaxi ShenDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.ORCID http://orcid.org/0000-0001-6540-8283
Yanan YuZhengzhou Key Laboratory of Cardiovascular Aging, Henan Province Key Laboratory for Prevention and Treatment of Coronary Heart Disease, National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital and Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China.
Liguo JianDepartment of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China. sahjlg@zzu.edu.cn.
Datun QiZhengzhou Key Laboratory of Cardiovascular Aging, Henan Province Key Laboratory for Prevention and Treatment of Coronary Heart Disease, National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital and Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China. qimedicine@zzu.edu.cn.
Wenting ZhaoThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 1320002@zju.edu.cn.
Dongdong JianZhengzhou Key Laboratory of Cardiovascular Aging, Henan Province Key Laboratory for Prevention and Treatment of Coronary Heart Disease, National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital and Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China. jdd1102@zzu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82100437Natural Science Foundation of Henan Province (Henan Province Natural Science Foundation) Natural Science Foundation of Henan ProvinceNatural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) MS25H020020
6 · The paper itself

Abstract

Atherosclerosis is the underlying cause of cardiovascular disease. Recent studies have shown that N

Indexed as

AtherosclerosisJumonji Domain-Containing Histone DemethylasesMacrophage ActivationMethyltransferasesRNA, MessengerRNA StabilitySTAT1 Transcription FactorAdenosineAnimalsHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutAdenosineJumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseMethyltransferasesMettl3 protein, mouseN-methyladenosineRNA, MessengerStat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID41423554
PMCPMC12800227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.