Diastereoselective synthesis of novel (S)-lactic pyrazoline derivatives and investigation of antibacterial capabilities.

Maryam Gholami, Gholamhassan Imanzadeh, Farhad Kabiri Esfahani, Morteza Karami-Zarandi, Amir Nasser Shamkhali

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Three privileged scaffolds, one pipeline: chalcones, pyrazolines and pyrazoles in drug discovery and fluorescent sensing.RSC medicinal chemistry · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam GholamiDepartment of Chemistry, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran.

Gholamhassan ImanzadehDepartment of Chemistry, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran. Imanzad2000@yahoo.com.

Farhad Kabiri EsfahaniDepartment of Chemistry, Faculty of Sciences, University of Zanjan, Zanjan, 45371-38791, Iran.

Morteza Karami-ZarandiDepartment of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, 45139-56111, Iran.

Amir Nasser ShamkhaliDepartment of Chemistry, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a novel series of diastereomerically enriched lactic-derived pyrazoline compounds 7(a-l) were synthesized via cyclocondensation of (S)-lactic Hydrazide with various substituted Chalcones under basic conditions. The methodology benefits from the inherent chirality of (S)-ethyl lactate, serving as a chiral precursor, allowing diastereoselectivity in the formation of (S,R)-pyrazoline derivatives. Structural confirmation was achieved using IR,

Indexed as

Anti-Bacterial AgentsLactic AcidPyrazolesMicrobial Sensitivity TestsStaphylococcus aureusStereoisomerismAnti-Bacterial AgentsLactic AcidPyrazolesAntibacterial propertiesChirality inductionDiastereoselective synthesis(S)-lactic hydrazide(S)-lactic pyrazoline

Identifiers

PMID41423475

DOI10.1038/s41598-025-32881-3

PMCPMC12830598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.