ArticleNature communications2025
Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Successive waves of transcriptional repression and de-repression license cell cycle progression in an archaeon.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Despite its fundamental importance for the propagation of all cellular life, very little is known about the molecular basis of chromosome segregation in archaea. This is a particularly intriguing issue in members of the genus Sulfolobus which encode homologs of a "bacterial-like" candidate segregation machinery, termed SegAB, related to the bacterial ParA-based systems, yet rely on a "eukaryotic-like" ESCRT machinery for cell division. While investigating the temporal dynamics of Sulfolobus chromosome architecture, we uncovered conformational changes at the candidate segregation locus. Loss of the Seg system results in altered nucleoid morphology and induction of a DNA damage response. Significantly, loss of the Seg system also leads to precocious assembly of the key cell division protein CdvA. Finally, we observe interactions between SegA and CdvA, indicating dual roles for the Seg system in effecting chromosome segregation and defining the positioning of the cell division apparatus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.