Evidence map›Paper›PMID 41423455›Full record

ArticleNature communications2025

Late-stage adenine N6-alkylation of nucleos(t)ides and oligonucleotides via photoredox and copper co-catalytic decarboxylative C(sp3)-N coupling.

Ruoqian Xie, Guolan Xiao, Wanlu Li, Wenhao Luochen, Madiha Butt, Yingchuan Que, Xiaorong Li, Yangyan Li, Litao Sun, Gang Chen

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In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruoqian Xie *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Guolan Xiao *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wanlu LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wenhao LuochenState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Madiha ButtState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yingchuan QueState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0003-5178-0019
Xiaorong LiSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Yangyan LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Litao SunSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.ORCID http://orcid.org/0000-0002-8415-989X
Gang ChenState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. gchen2018@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-1683-7676

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22271186,22001165
6 · The paper itself

Abstract

Nucleosi(ti)des and nucleic acids with N6 modified adenosine play an important role in the areas of disease diagnosis and treatment, biological chemistry, as well as nanotechnology. The conventional way to achieve N6 alkylation includes nucleophilic aromatic substitution reaction from N6 activated adenosine and direct reductive amination from adenosine. However, nucleophilic aromatic substitution reaction needs pre-functionalization of adenosine and reductive amination has limited alkyl substrate groups, especially not compatible with the secondary and tertiary alkyl groups. Herein, we develop a practical alkylation at the N6-position of adenines in adenosine and its analogues as well as late-stage functionalization of nucleotides/oligonucleotides through photoredox and copper co-catalyzed decarboxylative C(sp3)-N cross-coupling reaction. This method features simplicity and directness with various free radical precursors which is promising for medicinal and biological applications.

Indexed as

AdenineAdenosineCopperOligonucleotidesAlkylationCatalysisDecarboxylationOxidation-ReductionAdenineAdenosineCopperOligonucleotides

Identifiers

PMID41423455
PMCPMC12852761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.