Evidence map›Paper›PMID 41423165›Full record

ArticleNeuroImage2026

Abnormalities in sensorimotor brain function are related to chronicity of low back pain.

Jo Armour Smith, Rongwen Tain, Kelli G Sharp, Laura M Glynn, Linda R Van Dillen, Jesse V Jacobs, Steven C Cramer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jo Armour SmithDepartment of Physical Therapy, Chapman University, Irvine, CA, USA. Electronic address: josmith@chapman.edu.
Rongwen TainCampus Center for Neuroimaging, University of California, Irvine, CA, USA.
Kelli G SharpDepartment of Dance, School of Arts, Department of Physical Medicine and Rehabilitation, University of California, Irvine, USA.
Laura M GlynnDepartment of Psychology, Chapman University, Orange, CA, USA.
Linda R Van DillenProgram in Physical Therapy, Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, USA.
Jesse V JacobsRehabilitation and Movement Science, University of Vermont, VT, USA.
Steven C CramerDept. Neurology, University of California, Los Angeles; and California Rehabilitation Institute, Los Angeles, CA, USA.

Funding

The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.K01HD092612 · NICHD · CHAPMAN UNIVERSITY · PI SMITH, JO ARMOUR · 2018 to 2022
$639k
NICHD NIH HHS K01 HD092612
6 · The paper itself

Abstract

Maladaptive plasticity in the brain may contribute to chronic low back pain (LBP) and underlie the altered postural control of the lumbopelvic musculature that is evident in some individuals with LBP. We recently described an MRI-compatible leg-raise paradigm to measure brain activity associated with lumbopelvic postural control. The objective of this study was to compare brain function in young adults with and without a history of LBP and to determine relationships between brain function, pain, and postural control characteristics. We recruited 55 participants with a history of LBP, who were asymptomatic when studied, and 30 healthy controls. Postural control during leg-raise tasks were quantified using electromyography and ground reaction forces. Group differences in movement-related brain activation during the leg-raise tasks were assessed with fMRI and associations among brain activation, postural control, and pain characteristics were examined. Compared with controls, participants with LBP had greater activation in the angular gyri, posterior cingulate cortices; and greater peak signal change in the right angular gyrus, right pre-central gyrus, and left globus pallidus. Abnormal postural control was associated with greater activation in right pre-central gyrus and left posterior cingulate cortex. Worse pain characteristics associated with less activation in left posterior cingulate cortex and more activation in right angular gyrus. Pathological changes in movement-related brain function are evident early in the time-course of LBP, persist between symptomatic episodes, and associate with clinical characteristics. These findings suggest biomarkers of dysfunction in pain-related circuits associated with LBP and have implications for pathophysiology of this condition.

Indexed as

BrainChronic PainLow Back PainPostural BalanceSensorimotor CortexAdultBrain MappingElectromyographyFemaleHumansMagnetic Resonance ImagingMaleYoung AdultChronic back painfMRIPostural control

Identifiers

PMID41423165
PMCPMC12952534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.