Evidence map›Paper›PMID 41423148›Full record

ArticleJournal of pediatric surgery2026

Epithelial ion transport in spring-lengthened jejunum in a porcine model.

Nam Soo Joo, Anne-Laure Thomas, Fereshteh Salimi-Jazi, Talha A Rafeeqi, Gillian Fell, Pamela Emengo, Julie-Ann Nguyen, Modupeola Diyaolu, Shayda Abazari, Zachary M Sellers and 1 more

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In one paragraph

Article in Journal of pediatric surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nam Soo JooDepartment of Pediatrics, Stanford University School of Medicine, Stanford CA, USA; Division of Pediatric Pulmonology, Stanford University School of Medicine, Stanford CA, USA.
Anne-Laure ThomasDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Fereshteh Salimi-JaziDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Talha A RafeeqiDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Gillian FellDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Pamela EmengoDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Julie-Ann NguyenDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Modupeola DiyaoluDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA.
Shayda AbazariDepartment of Pediatrics, Stanford University School of Medicine, Stanford CA, USA.
Zachary M SellersDepartment of Pediatrics, Stanford University School of Medicine, Stanford CA, USA; Sellers Research and Clinical Development Consulting, LLC, Newark, CA, USA.
James C Y DunnDepartment of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, Stanford CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: jdunn2@stanford.edu.

Funding

Spring Mediated EnterogenesisR01DK130972 · NIDDK · STANFORD UNIVERSITY · PI James C Dunn · 2021 to 2026
$1.8M
NIDDK NIH HHS R01 DK130972
6 · The paper itself

Abstract

BACKGROUND AND

aimLoss of functional small intestine in short bowel syndrome results in profound nutrient malabsorption and diarrhea. We previously developed an expandable spring device that triggers intestinal lengthening. The aim of this study was to assess the functional ion transport capabilities of spring-lengthened jejunum.

methodMini-Yucatan pigs underwent laparotomy and spring placement in the jejunum. After 7 days, pigs were euthanized to retrieve spring-lengthened and distal control jejunum. Tissues were mounted in Ussing chambers to measure transepithelial resistance and short-circuit current (I

resultsIntestinal segments exposed to springs became longer at euthanasia. Baseline transepithelial resistance and I

conclusionSpring-lengthening of small bowel does not disrupt mucosal barrier function, based on histological and functional assessments. While spring-lengthened jejunum showed reduced transepithelial secretory function, its absorptive function appears intact. This change may be related to early tissue remodeling during distraction enterogenesis and further investigation into the cellular changes induced by distraction enterogenesis are ongoing.

Indexed as

Intestinal MucosaIon TransportJejunumShort Bowel SyndromeAnimalsCarbacholColforsinDisease Models, AnimalGlucoseModels, AnimalSwineSwine, MiniatureCarbacholColforsinGlucoseGlucose transportIntestinal lengtheningIon transportShort bowel syndromeUssing chambers

Identifiers

PMID41423148
PMCPMC13549452

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.