Evidence map›Paper›PMID 41423065›Full record

ReviewTrends in cardiovascular medicine2026

The Yin and Yang of cellular senescence in ischemia-induced myocardial injury.

Rosalie Wolff von Gudenberg, Jasper Iske, Tobias Roeschl, Philipp Stawowy, James L Kirkland, Arjang Ruhparwar, Stefan G Tullius

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosalie Wolff von GudenbergDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg Straße 1, 30625 Hannover, Germany.
Jasper IskeDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, 13353 Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Tobias RoeschlCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Cardiology, German Heart Center Berlin, Mittlallee 11,13353 Berlin, Germany.
Philipp StawowyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Cardiology, German Heart Center Berlin, Mittlallee 11,13353 Berlin, Germany.
James L KirklandCenter for Advanced Gerotherapeutics, Department of Medicine, Cedars-Sinai Health Sciences University, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90069, USA.
Arjang RuhparwarDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg Straße 1, 30625 Hannover, Germany.
Stefan G TulliusDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: stullius@bwh.harvard.edu.

Funding

The KAPP-Sen Tissue Mapping Center CollaborativeU54AG075941 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GAROVIC, VESNA D, KUCHEL, GEORGE A · 2021 to 2025
$13.8M
Nano Immune-Imaging CoreP01AI175397 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Reza Abdi, Stefan Gunther Tullius · 2024 to 2026
$9.5M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Translational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2M
Senescent cells drive mt-DNA accumulation and inflamm-agingR01AG064165 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2020 to 2024
$2.6M
Understanding Interorgan Communication Through Heterochronic Organ TransplantationU01AG086168 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Vadim N. Gladyshev, Stefan Gunther Tullius · 2024 to 2026
$2.0M
NIAID NIH HHS P01 AI175397NIA NIH HHS R01 AG064165NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS U01 AG086168NIA NIH HHS U54 AG075941
6 · The paper itself

Abstract

Cellular senescence is a stress responsive program that critically affects chronological and biological aging, ischemia reperfusion injury (IRI), and age related cardiovascular diseases. Of relevance, cardiac senescent cells exhibit altered characteristics that promote inflammation, remodeling, and fibrosis, ultimately contributing to the functional decline following myocardial infarction (MI). At the same time, emerging evidence suggests that senescence may also exert protective effects post-MI, limiting fibrosis. Thus, understanding the mechanisms and pathways of cardiac senescence appears critical for delineating the consequences of IRI, including identification of novel therapeutic targets for improving post-MI recovery.

Indexed as

Cellular SenescenceMyocardial InfarctionMyocardial IschemiaMyocardial Reperfusion InjuryMyocardiumAnimalsFibrosisHumansSignal Transduction

Identifiers

PMID41423065
PMCPMC12832129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.