Evidence map›Paper›PMID 41422350›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Cuticular drusen in Asian neovascular age-related macular degeneration: Clinical features and polypoidal choroidal vasculopathy association.

Chenxi Zhang, Noa Gilead, Zehua Jiang, Beau J Fenner, Anna Cs Tan, Hiok Hong Chan, Kelvin Yi Chong Teo, Chui Ming Gemmy Cheung

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chenxi ZhangMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Noa GileadMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Zehua JiangMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Beau J FennerMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Anna Cs TanMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Hiok Hong ChanMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Kelvin Yi Chong TeoMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Chui Ming Gemmy CheungMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. gemmy.cheung.c.m@singhealth.com.sg.ORCID 0000-0003-3358-3516

Funding

National Medical Research Council Open Fund Large Collaborative Grant OFLCG23 may-0032
6 · The paper itself

Abstract

purposeTo characterize the clinical features of cuticular drusen (CD) in Asian patients with neovascular age-related macular degeneration (nAMD), and to evaluate its association with polypoidal choroidal vasculopathy (PCV) and the risk of macular neovascularization (MNV).

methodsBaseline multimodal images from a prospective Asian nAMD cohort were analyzed. Patients were classified into cuticular drusen (CD), soft drusen (SD), or no drusen (ND) groups based on multimodal imaging. Patients were assigned to the CD group if CD was present in either eye, regardless of the presence of other drusen types. Patients without CD but with SD in one or both eyes were assigned to the SD group. Patients with no drusen in either eye were assigned to the ND group. Clinical and imaging features were compared. MNV lesions were subtyped as PCV or typical nAMD. For eyes without MNV at baseline, the 5-year cumulative incidence of MNV was estimated using Kaplan–Meier analysis.

resultsA total of 104 patients (173 eyes) were included: 16 with CD (21 eyes), 43 with SD (62 eyes), and 45 with ND (90 eyes). CD patients were older (75.5 ± 9.1 years) compared to ND patients (66.2 ± 7.4 years, p < 0.001). There was no significant difference in gender distribution between patients with CD, SD and ND. CD eyes had shorter axial length than ND (p = 0.004) and commonly coexisted with large (> 200 μm) soft/ colloid drusen (66.7%) and subretinal drusenoid deposits (33.3%). MNV was present in 52.3% of CD eyes, with 54.5% classified as PCV, which was intermediate to SD (25.0%) and ND (74.5%). Among CD eyes without baseline MNV, the 5-year incidence was 11.1%, also intermediate to ND (0.0%) and SD (38.2%).

conclusionIn this Asian nAMD cohort, patients with CD were older with a more balanced gender distribution. Its notable association with PCV and MNV risk highlights the need for continued monitoring and further investigation.

Indexed as

ChoroidFluorescein AngiographyPolypoidal Choroidal VasculopathyRetinal DrusenVisual AcuityWet Macular DegenerationAgedAged, 80 and overBruch MembraneEye Diseases, HereditaryFemaleFollow-Up StudiesFundus OculiHumansIncidenceMaleAsian populationCuticular drusenMacular neovascularizationPolypoidal choroidal vasculopathy

Identifiers

PMID41422350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.