Evidence map›Paper›PMID 41422253›Full record

ArticleJournal of nanobiotechnology2025

Nitric oxide-releasing nanocarriers integrated with ginsenoside compound K in dissolvable microneedles for androgenetic alopecia.

Guanghui Sun, Jianlin Liu, Guorui Jin, Jing Zhao, Xiaoyang Li, Xueqing Yu, Yu Mi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guanghui SunEngineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China.
Jianlin LiuSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
Guorui JinThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Bioinspired Engineering and Biomechanics Center (BEBC), School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Jing ZhaoEngineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China.
Xiaoyang LiEngineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China.
Xueqing YuEngineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China. yuxueqing@nwu.edu.cn.
Yu MiEngineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China. mi_yu@nwu.edu.cn.

Funding

Scientific Research Projects of Shaanxi Provincial Department of Education 24JK0672the National Natural Science Foundation of China 22408292
6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is recognized as a prevalent androgen-mediated disorder characterized by progressive follicular miniaturization and irreversible hair loss, primarily driven by the pathological elevation of dihydrotestosterone (DHT) that disrupts hair follicle microenvironment and induces follicular cells damage. This condition frequently results in profound psychosocial distress and diminished quality of life among affected individuals. In this study, we introduced a novel microneedle-based drug delivery system (CK/GSNO@Lip MN) for the synergistic treatment of AGA. The system was ingeniously engineered for the co-delivery of Ginsenoside Compound K (CK) and S-nitrosoglutathione (GSNO), which possessed distinct hydrophobicities and release kinetics. Specifically, the hydrophobic drug CK activated the PI3K-AKT signaling pathway to upregulate β-catenin expression, while concurrently modulating reactive oxygen species (ROS) levels and alleviating excessive inflammatory responses. Meanwhile, the hydrophilic nitric oxide (NO) donor GSNO released NO to enhance angiogenesis and synergistically regulated inflammatory homeostasis in conjunction with CK, thereby creating a favorable microenvironment for hair regeneration. Ultimately, CK/GSNO@Lip MN achieved significant hair regeneration by modulating the hair follicle microenvironment and promoting the proliferation of follicular cells. This innovative therapeutic strategy provided a comprehensive approach to AGA treatment, with promising potential for broader dermatological applications.

Indexed as

AlopeciaDrug CarriersGinsenosidesNitric OxideAnimalsDrug Delivery SystemsHair FollicleHumansMaleMiceNeedlesReactive Oxygen SpeciesS-NitrosoglutathioneDrug CarriersGinsenosidesNitric OxideReactive Oxygen SpeciesS-NitrosoglutathioneAndrogenetic alopeciaGinsenoside com-pound kHair follicle microenvironm-entMicroneedle drug deliveryPI3K-AKT pathwayS-nitrosoglutathione

Identifiers

PMID41422253
PMCPMC12831260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.